Press Release
Communiqué de presse
–
March 17, 2022
17 March, 2022
Data Safety Monitoring Board Recommends Continuation of Phase 1/2 Clinical Trial with Sernova’s Cell Pouch System™ in Patients with Type-1 Diabetes
Confirms Ongoing Safety and Tolerability of Sernova’s Cell Pouch
March 17, 2022 10:00 a.m. EDT
LONDON, ONTARIO – March 17, 2022 – Sernova Corp. (TSX-V:SVA)(OTCQB:SEOVF)(FSE:PSH), a clinical-
stage company and leader in regenerative medicine cell therapeutics, is pleased to announce that the Data
Safety Monitoring Board (“DSMB”) has completed the third annual review of Sernova’s ongoing Phase 1/2
clinical study “Safety, Tolerability and Efficacy Study of Sernova’s Cell Pouch for Clinical Islet Transplantation”
in patients with Type-1 Diabetes (T1D) who suffer from hypoglycemia unawareness and severe hypoglycemic
events.
In their assessment, the DSMB recommended that the clinical study should continue according to the study
plan.
The DSMB is an independent committee of clinical experts who review the accumulated trial data to evaluate
patient safety and ensure the integrity of the study data.
“This recommendation from the DSMB affirms our understanding of the safety of Cell Pouch in this patient
population transplanted with human donor islets. We look forward to sharing updates from the study through
upcoming conference presentations by Dr. Piotr Witkowski, the trial Principal Investigator.” said Dr. Philip
Toleikis, President & CEO of Sernova Corp.
For more information on this clinical trial, please visit www.clinicaltrials.gov/ct2/show/NCT03513939. For
more information on enrollment and recruitment details please visit www.pwitkowski.org/sernova.
ABOUT HYPOGLYCEMIA UNAWARENESS
Hypoglycemia unawareness is a person’s inability to recognize the symptoms of low blood sugar before they
become severe enough to be incapacitating or even fatal, which may occur when blood glucose levels are
below 3.0 mmol/L. It is estimated that approximately 15% of people with T1D, or approximately 240,000
people, are affected by hypoglycemia unawareness in the US alone.
Severe symptoms of low blood sugar include confusion, slurred speech, impaired motor coordination and
personality changes. Individuals experiencing a severe hypoglycemic event can lose their ability for self-care
and self-control, requiring urgent intervention from another person to prevent loss of consciousness, seizure,
coma, or death. After a person has had a first hypoglycemia unawareness episode, more are likely to occur.
ABOUT SERNOVA
Sernova is developing regenerative medicine cell therapeutic solutions using a medical device (Cell Pouch) and
immune protected therapeutic cells / tissues (i.e. human donor cells, corrected human cells and stem cell-
derived cells) to improve the treatment and quality of life of people with chronic metabolic diseases such as
insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through cellular
production of proteins or hormones missing or in short supply within the body. For more information, please
visit www.sernova.com.
ABOUT SERNOVA’S CELL POUCH SYSTEM CELL THERAPY PLATFORM
The Cell Pouch, as part of the Cell Pouch System, is a novel, proprietary, scalable, implantable macro-
encapsulation device solution designed for the long-term survival and function of therapeutic cells. After
implantation, the device incorporates with tissue, forming highly vascularized, native tissue chambers for the
transplantation and function of therapeutic cells, that release proteins and hormones as required to treat
disease.
The Cell Pouch, along with therapeutic cells, has been shown to provide long-term safety and efficacy in small
and large animal models of diabetes and has been proven to provide a biologically compatible environment for
insulin-producing cells in humans in a Canadian first-in-human study. Sernova is currently conducting a Phase
1/2 clinical trial study at the University of Chicago. Positive initial results have been presented at several
international scientific conferences.
FOR FURTHER INFORMATION, PLEASE CONTACT:
Christopher Barnes
VP, Investor Relations
Sernova Corp.
christopher.barnes@sernova.com
Tel: 519-902-7923
www.sernova.com
Corey Davis, Ph.D.
LifeScience Advisors, LLC
cdavis@lifesciadvisors.com
Tel: 212-915-2577
FORWARD-LOOKING INFORMATION
This release contains statements that, to the extent they are not recitations of historical facts, may constitute
“forward-looking statements” that involve various risks, uncertainties, and assumptions, including, without
limitation, statements regarding the prospects, plans, and objectives of the company. Wherever possible, but
not always, words such as “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”,
“potential for” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or
“should” occur are used to identify forward-looking statements. These statements reflect management’s
beliefs with respect to future events and are based on information currently available to management on the
date such statements were made. Many factors could cause Sernova’s actual results, performances or
achievements to not be as anticipated, estimated or intended or to differ materially from those expressed or
implied by the forward-looking statements contained in this news release. Such factors could include, but are
not limited to, the company’s ability to secure additional financing and licensing arrangements on reasonable
terms, or at all; ability to conduct all required preclinical and clinical studies for the company’s Cell Pouch
System and/or related technologies, including the timing and results of those trials; ability to obtain all
necessary regulatory approvals, or on a timely basis; ability to in-license additional complementary
technologies; ability to execute its business strategy and successfully compete in the market; and the inherent
risks associated with the development of biotechnology combination products generally. Many of the factors
are beyond our control, including those caused by, related to, or impacted by the novel coronavirus pandemic.
Investors should consult the company’s quarterly and annual filings available on www.sedar.com for additional
information on risks and uncertainties relating to the forward-looking statements. Sernova expressly disclaims
any intention or obligation to update or revise any forward-looking statements, whether as a result of new
information, future events or otherwise.