2014 Press Releases Communiqués de presse

November 9, 2014 9 November, 2014

SERNOVA PROVIDES CORPORATE UPDATE

July 14, 2014 14 July, 2014

SERNOVA AGREES ON TERMS TO GAIN ACCESS TO PROPRIETARY STEM CELL TECHNOLOGY

June 2, 2014 2 June, 2014

Sernova Provides Corporate Update and Results of 2014 Annual General Meeting

May 13, 2014 13 May, 2014

Sernova Receives Patent Allowance for Cell Pouch™ and Therapeutic Cell Transplantation Technologies

May 11, 2014 11 May, 2014

Kevin Egan Joins Sernova as Chair Business Advisory Board

May 6, 2014 6 May, 2014

Sernova Announces Appointment of Nick Borrelly to Corporate Development Role

April 21, 2014 21 April, 2014

Sernova’s Cell Pouch™ Diabetes Clinical Trial Demonstrates Interim Safety and Biocompatibility

February 25, 2014 25 February, 2014

Sernova Announces Annual Meeting, Record Date and Adopts Advance Notice By-Law

February 10, 2014 10 February, 2014

Frank Holler Joins Sernova’s Board of Directors

January 30, 2014 30 January, 2014

Sernova Announces Appointment of Cathy Steiner as CFO

January 12, 2014 12 January, 2014

Sernova to Present Company and Clinical Update at Biotech Showcase™ Healthcare Conference in San Francisco

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Press Release Communiqué de presse - November 09, 2014 9 November, 2014

SERNOVA PROVIDES CORPORATE UPDATE


ADVANCES MADE IN CELL POUCH(TM) CLINICAL DEVELOPMENT AND POSITIVE OUTLOOK FOR COMPANY’S NEW THERAPEUTIC CELL TECHNOLOGIES

Source: Sernova Corp

FOR RELEASE November 10th, 2014, 6:00 a.m. EST

LONDON, ONTARIO--(Marketwire – November 10th, 2014) - Sernova Corp. (TSX-V: SVA), a clinical stage company developing cell therapy technologies for the long-term treatment of chronic debilitating metabolic diseases including diabetes and hemophilia, today provides a corporate update, summarizing advances made in the clinical development of its Cell Pouch(TM) over the past 12 months and the application of its technologies to new disease indications.

Cell Pouch(TM) Clinical Initiatives

The clinical assessment of the Cell Pouch(TM) in brittle diabetic patients with hypoglycemia unawareness who have received an islet transplant has shown in a small cohort of patients in interim analysis that the Cell Pouch(TM) is biocompatible and safe following implant and transplant. Safety is the primary endpoint of the study. Initial data from the study have shown the following three important findings:

• First, biocompatibility and a positive safety profile of the Cell Pouch(TM) have been shown in the first cohort of patients.

• Second, the islets within the Cell Pouch(TM), as shown by histological analysis, are well-vascularized, living within a natural tissue matrix and are able to make insulin, glucagon and somatostatin, key hormones in the control of blood glucose levels. We believe such revascularization of islets and islet metabolic function within an implantable medical device for therapeutic cells in humans in this patient population is a first in the regenerative medicine field.

• Third, these positive developments of the study suggest that Sernova’s Cell Pouch(TM) may form a suitable environment for the survival and function of multiple types of therapeutic cells including human stem cells which can represent a virtually unlimited supply of cells for treating disease.

“Sernova has achieved a major milestone with its first-in-human testing”, remarked Dr. James Shapiro, Principal Investigator for the diabetes study. “Our respective scientific teams are moving ahead to accelerate the pace of innovation, and believe the Cell Pouch(TM) is a highly promising vehicle for transplantation of future stem cell therapies”.

With the encouraging pre-clinical and interim clinical results, Sernova maintains its longer term strategy and objective to achieve a complete solution for treatment of insulin-dependent diabetes, including access to an unlimited supply of insulin producing tissue such as that developed from stem cell technologies, and protection from immune system attack using local immune protection technologies within the pre-vascularized Cell Pouch(TM).

Research and Development Collaboration with Dr. Shapiro

In an independent pre-clinical study, it has been shown that the Cell Pouch(TM) provided insulin independence for 100 days in a small animal model of diabetes using a marginal (minimal) transplanted islet mass. The encouraging results of this study will be released in more detail upon acceptance for publication in a peer reviewed medical journal.

Hemophilia Collaboration with Medicyte GmbH

The research and development teams at Medicyte and Sernova are continuing to work closely in the development of a product to treat Hemophilia A patients. This product involves taking a small blood sample from the patient, correcting the genetic defect in isolated cells and then using Medicyte’s upcyte® technology to expand the cell numbers for placement into the Cell Pouch(TM) for release of Factor VIII. The teams are currently conducting proof of concept studies which include cell isolation, processing and scale-up, product release and preclinical evaluation. Once these studies are successfully completed, the next steps will include GMP manufacturing of the cells and formal pre- clinical studies in preparation for human clinical trials.

New Cell Pouch(TM) Clinical Indications for Metabolic Disorders

As the Company continues its work on the diabetes and hemophilia indications, we are pursuing new autograft (self-cell) and/or allograft (donor-cell) clinical indications with academic and corporate collaborators to further expand the application of its cell therapy platform technologies. We plan to announce these further applications as new development agreements are signed.

Patent Developments

A strong patent portfolio covering the Company’s cell therapy technologies is an essential part of our business and an important element for attracting large pharma development partners. As such, we have put resources into developing our international patent portfolio and continue to be successful with the ongoing process of international patent prosecution involving the Company’s medical device, therapeutic cell and local immune protection technologies. We currently have achieved 25 issued patents and 27 pending patents in 9 patent families.

Development of Strategic Business Partnerships

As part of our partnering and licensing strategy, Sernova has hired a business development team with extensive experience with in-licensing technologies and developing corporate partnerships with emerging and large pharma/medical device companies. These activities broaden the company’s technology base, validate our technologies, and may provide additional funding sources and expertise to advance our clinical programs to product approval. In this regard, we are in business discussions with a number of companies with complementary technologies which we expect to result in collaborations to develop new products.

“With its GMP manufactured product, years of strong pre-clinical results and encouraging clinical safety, Sernova’s Cell Pouch(TM) is becoming recognized as an elegant delivery module. We are expanding our relationships with a number of therapeutic cell companies who have interest in their ‘therapeutic cell payload’ being paired with our technologies,” remarked Kevin Egan, Chair of Sernova’s business advisory board. “The pharmaceutical companies we are in discussions with see the Cell Pouch(TM) in conjunction with our local immune protected cell-based technologies as the total regenerative medicine package to treat serious chronic diseases.”

Grant Funding

The Company has applied for and continues to seek non-dilutive sources of funding in the form of government and non-profit society grants which can result in funding for the Company’s ongoing and new research and development programs to support our treasury. The Company has to date secured over $1.0 million in such grants.

Selected Highlighted Corporate Developments

Following are highlights of significant recent developments at Sernova:

• Released positive interim results from our human clinical trial of the Cell Pouch(TM) with insulin producing islets for the treatment of Type I diabetes, demonstrating tissue biocompatibility and safety for up to 6 months, as well as proof of 30 day islet survival within the Cell Pouch™ following islet transplant.

• Established an agreement with Medicyte GmbH and initiated pre-clinical studies to jointly evaluate the use of Medicyte’s upcyte® cells in Sernova’s Cell Pouch(TM) to treat patients with Hemophilia A disease.

• Received the first patent allowance for Methods and Devices for Cellular Transplantation from the Australian Patent Office and further allowances in additional jurisdictions.

• Continued evaluation of our local immune protection technology within the Cell Pouch(TM) for treatment of chronic diseases following receipt of a contribution agreement for up to $254,300 from the National Research Council of Canada for continued research and development.

• Appointed biopharma entrepreneur and investor Frank Holler to the Board of Directors.

• Established a world class business development team to establish corporate partners for Sernova’s programs and to expand Sernova’s proprietary technologies through academic and corporate partnerships.

“We are making solid progress on multiple fronts as we continue to develop our platform technologies in the regenerative medicine arena”, stated Dr. Philip Toleikis, Sernova’s President and CEO. “The further success in our international intellectual property patent development, pursuit of stem cell technologies to gain a virtually unlimited supply of cells to treat diabetes, expansion of our research and development programs into new disease indications, and expansion of our management team in business and corporate development all demonstrate our long-term commitment to develop our promising therapeutic cell technologies into products that markedly improve patient outcomes.”

About Sernova

Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technologies.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Ray Matthews Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information

This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - July 14, 2014 14 July, 2014

SERNOVA AGREES ON TERMS TO GAIN ACCESS TO PROPRIETARY STEM CELL TECHNOLOGY


Sernova’s advanced technologies aim to provide individuals with insulin-dependent diabetes freedom from insulin injections, pumps and daily blood glucose monitoring

Source: Sernova Corp FOR RELEASE July 15th, 2014, 6:00 a.m. EDT

LONDON, ONTARIO – (Marketwire – July 15, 2014) – Sernova Corp. (TSX-V: SVA) a clinical stage company developing medical technologies for the long-term treatment of chronic metabolic diseases including diabetes, blood disorders such as haemophilia and other diseases announced today it has agreed on key terms with the University Health Network of Toronto (UHN) to gain access to worldwide, exclusive rights to certain patent-pending technologies developed by distinguished UHN researchers, Dr. Cristina Nostro and Dr. Gordon Keller, for the advancement of insulin-producing stem cells for the treatment of patients with insulin-dependent diabetes.

Sernova and UHN have entered into a Term Sheet with an exclusive negotiation period which outlines the terms of the definitive license agreement for the granting of an exclusive license to Sernova covering all patent rights relating to the UHN stem cell technologies including for the treatment of diabetes. A product development program is also being designed to advance the technologies from preclinical proof-of-concept studies through to human testing on an expedited basis.

Sernova believes the proprietary product – insulin producing stem cells, protected locally from immune system attack and placed within Sernova’s prevascularized Cell Pouch(TM) – has the potential to provide a significant break-through in the quality of treatment for the millions of people suffering from insulin-dependent diabetes, following successful preclinical and clinical testing. Such individuals could essentially be liberated from their current onerous regime of daily blood glucose testing and insulin administration delivered through injections or electronic means which is expected to materially improve their quality of life while also reducing short term and longer term health care costs.

Dr. Philip Toleikis, CEO of Sernova remarked, “Upon execution of the definitive licensing agreement, Sernova will have exclusive rights to the UHN stem cell technologies. With this agreement we will have access to the full complement of technologies necessary to develop an advanced cell-based treatment for the millions of people who have insulin-dependent diabetes. Current standard of care for islet transplantation is limited to only the sickest of people with diabetes due to both a lack of cadaveric donor islet cells and a requirement for life-long use of toxic anti-rejection drugs.”

Dr. Toleikis continued, “Markedly improving the standard of care for insulin dependent diabetes is an important objective for our Company and a key interest for the families who have been seeking a break-through in the quality of treatment for many years. We believe that combining the expertise and experience of Sernova’s internal R&D team, UHN’s stem cell team, and diabetes clinicians and researchers, such as Dr. James Shapiro and other investigators, will serve to maximize the probability of bringing this advanced treatment to commercialization.”

Remarked Kevin Egan, Chair of Sernova’s Business Advisory Board, “Combining Sernova’s regenerative medicine technologies with those of the UHN stem cell program could produce the next generation of islet transplant therapy for insulin-dependent diabetes patients. We anticipate that Sernova’s therapy should also open up new avenues for partnering discussions with pharmaceutical and biotechnology companies developing new breakthrough treatments for this debilitating disease.”

Sernova’s rights to the UHN stem cell technologies are subject to negotiation and execution of a definitive license agreement with UHN based on the signed term sheet.

About Diabetes The worldwide incidence of diabetes is approximately 370 million people. Sernova’s potential addressable market which includes Type-1 patients and those Type-2 patients requiring insulin is over 30 million people. Although there is no cure for diabetes, blood glucose levels are currently being controlled with frequent blood glucose testing combined with regular injections of insulin via syringe or insulin pump. However, blood glucose control using this treatment approach can be poor, leading to side effects such as heart, kidney and eye diseases as well as ischemia-induced amputations. According to the Juvenile Diabetes Research Foundation, annual health care costs for the treatment of diabetes and its debilitating side effects are estimated to be over US $245 billion per year in North America (http://jdrf.org/).

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technologies.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Ray Matthews Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Forward-looking information in this news release includes the expectation of completing a definitive license agreement with UHN and Sernova’s ability to successfully combine our product with UHN technology to improve the lives of diabetes patients while lowering healthcare costs. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - June 02, 2014 2 June, 2014

Sernova Provides Corporate Update and Results of 2014 Annual General Meeting


June 3rd, 2014, 6:00 a.m. EST LONDON, ONTARIO--(Marketwire – June 3rd, 2014) - Sernova Corp. (TSX-V: SVA), a clinical stage company developing medical technologies for the long-term treatment of chronic debilitating metabolic diseases including diabetes and haemophilia today provides a corporate update and results of its 2014 Annual General Meeting (AGM).

Dr. Philip Toleikis, CEO of Sernova, commented “This is an exciting time for Sernova. We are continuing our Cell Pouch(TM) clinical trial with Dr. James Shapiro of the University of Alberta for the treatment of Type I diabetes, and have reached agreement with Medicyte Gmbh for the initiation of proof of concept studies of our Cell Pouch (TM) with Factor VIII producing cells to treat haemophilia. We have also increased our board membership and brought on several seasoned business development members to assist the Sernova team as we further develop the Company.”

Dr. Toleikis further stated, “Along with our current programs, we are seeking to develop additional clinical applications for the Cell Pouch(TM), and our new business development team is in discussions with other potential corporate and academic partners to further expand the depth of our technologies. These advances should continue to build shareholder value and benefit patients with chronic diseases.”

Selected 2013 and 2014 Corporate Developments Following are highlights of significant developments at Sernova during the past year: • Released positive interim results from our human clinical trial of the Cell Pouch(TM) with insulin producing islets for the treatment of Type I diabetes, demonstrating biocompatibility and safety for up to 6 months, as well as proof of 30 day islet survival within the Cell Pouch™ following islet transplant. The clinical trial is ongoing. • Established an agreement with Medicyte GmbH and initiated preclinical studies to jointly evaluate the use of Medicyte’s upcyte® cells in Sernova’s Cell Pouch(TM) to treat patients with haemophilia A. • Received the first patent allowance for Methods and Devices for Cellular Transplantation from the Australian Patent Office. • Continued evaluation of our Sertolin(TM) local immune protection technology within the Cell Pouch(TM) for treatment of chronic diseases following receipt of a contribution agreement for up to $254,300 from the National Research Council of Canada for continued research and development. • Closed non-brokered private placement of $2 million, comprising 10 million units at a price of $0.20. Each unit consisted of 1 common share and 1 common share purchase warrant exercisable at $0.35 for the first 24 months and $0.40 for the subsequent 12 months. • Appointed biopharma entrepreneur and investor Frank Holler to the Board of Directors. • Established a world class business development team of Kevin Egan and Nick Borrelly to establish corporate partners for Sernova’s programs and to expand Sernova’s proprietary technologies through academic and corporate partnerships. • Appointed Mr. David Garland CPA CA, CPA CMA, MAcc, BA(Hon) as interim CFO to replace Ms. Cathy Steiner, who has moved on to pursue other business interests. Mr. Garland has extensive public company experience and has been CFO of Highcourt Partners, LTD, Mash Media Solutions, Inc., and Wi-LAN V-chip Corp and has worked as VP Finance and/or Controller at Pathways to Education, Certicom Corp, and Delano Technology Corporation. 2014 AGM Appointments • Dr. George Adams (Chair), Frank Holler, Jeffrey Bacha, James Parsons, Bruce Weber and Dr. Philip Toleikis, were elected as the directors of the Company to hold office until the next annual general meeting of shareholders. • Davidson & Company, Chartered Accountants, was appointed auditor of the Company until the close of the next annual general meeting of shareholders, at a remuneration to be fixed by the Directors.

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technologies.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Ray Matthews Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - May 13, 2014 13 May, 2014

Sernova Receives Patent Allowance for Cell Pouch™ and Therapeutic Cell Transplantation Technologies


Source: Sernova Corp May 14, 2014, 6:00 a.m. EDT

LONDON, ONTARIO (Marketwire – May 14, 2014) - Sernova Corp. (TSX-V: SVA), today announced that the Australian Patent Office has issued a Notice of Acceptance to Sernova for its patent application entitled "Methods and Devices for Cellular Transplantation.”

This patent covers Sernova’s entire Cell Pouch(TM) system of therapeutic cells, the Cell Pouch(TM) and its surgical tools for cell transplantation. The allowance of this patent will provide Sernova with patent protection through 2030. Similar patent applications have been filed in multiple countries around the world and have a higher likelihood of being granted now that the Australian one has been allowed.

"With this patent allowance, Sernova is now advancing to secure exclusive patent rights globally of our core technologies,” stated Dr. Philip Toleikis, Sernova's President and CEO. “This patent allowance is timely as intellectual property is a key element in attracting partners, which is the focus of our new world-class business development team.”

“The transition of intellectual property from a patent application to an allowed patent is a key component in strengthening the valuation of a technology”, said Kevin Egan, Chair of Sernova’s Business Advisory Board. “The fact that Sernova has achieved this for its platform technologies significantly increases its value and potential to partner with a major pharmaceutical or medical device company.”

When transplanted into Sernova’s Cell Pouch(TM), a safe, protected and efficacious environment is provided for therapeutic cells such as insulin-producing islets for the treatment of diabetes, as demonstrated in multiple preclinical studies.

In human patients with diabetes, the Cell Pouch(TM), transplanted with insulin producing islets, in interim analyses, has been shown to be biocompatible and safe as the primary objective of a clinical study at the University of Alberta with Dr. James Shapiro as principal investigator.

Sernova is exploring the additional utility of the Cell Pouch(TM) an enabling platform for a range of diseases such as haemophilia with Medicyte Gmbh and to maintain calcium homeostasis in kidney disease through parathyroid gland transplantation.

About Sernova

Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary local immune protection technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - May 11, 2014 11 May, 2014

Kevin Egan Joins Sernova as Chair Business Advisory Board


Experienced Biotechnology Executive and Investor to Contribute Strategic Business Development Expertise to Sernova

Source: Sernova Corp FOR RELEASE May 12th, 2014, 6:00 a.m. EDT

LONDON, ONTARIO--(Marketwire – May 12th, 2014) - Sernova Corp. (TSX-V: SVA) is pleased to announce that Mr. Kevin M. Egan, President, Borealis Biotechnology LLC, an international biotechnology consulting company, has joined Sernova as Chair of the Business Advisory Board. A Washington-based entrepreneur and investor, Mr. Egan is one of North America’s most prolific, biotech entrepreneurs, bringing over 25 years of success-driven experience in biopharma, and commercialization & partnering expertise to Sernova. He has been directly involved in helping to develop blockbuster drugs from two, bell-weather US biotech giants: Amgen and Icos.

“We are elated to have a seasoned biotech business development colleague join Sernova at this exciting juncture”, remarked Dr. Philip Toleikis, President & CEO. “In addition to Cialis, Mr. Egan worked on two Amgen blockbuster drugs – Epogen, also known as Erythropoietin, which is a red blood cell hormone used primarily for treating people with anemia caused by a variety of diseases; and Neupogen – also known as GCSF, which is a white blood cell growth factor used extensively during chemotherapy. These biopharmaceuticals, along with their derivatives, are among the biggest selling pharmaceuticals of all time”, added Dr. Toleikis.

"I am pleased to be joining Sernova at a time when pharma is looking for disruptive technologies to bolster their pipelines," said Mr. Egan. "I am looking forward to working with Dr. Toleikis, and the industry-recognized team he has assembled, to advance Sernova's therapeutic cell-based product development programs and drive value for shareholders."

Mr. Egan began his career at Amgen, Inc. where he worked in research for ten years. In addition to negotiating licensing, partnering, and outsourcing agreements for both biologics and small molecules he was responsible for building and running ICOS’ biologics manufacturing business including marketing, business development, and managing the P&L. Over the course of his career, Mr. Egan has negotiated and closed over 100 contracts and agreements with companies from the U.S., Canada, Europe, Australia, Israel, Japan and Taiwan. To date he has brought in over $150M in revenue for various contract manufacturing organizations.

Mr. Egan has an MBA from the University of Washington, a Master’s degree in Biochemistry and Molecular Biology from U.C. Santa Barbara, and undergraduate degrees in Biology and Chemistry from U.C. Santa Cruz.

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary local immune protection technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - May 06, 2014 6 May, 2014

Sernova Announces Appointment of Nick Borrelly to Corporate Development Role


Seasoned biopharma executive brings corporate development expertise to Sernova

Source: Sernova Corp FOR RELEASE May 7th, 2014, 6:00 a.m. EDT

LONDON, ONTARIO--(Marketwire – May 7th, 2014) - Sernova Corp. (TSX-V: SVA) is pleased to announce that Mr. Nick Borrelly is joining Sernova in a consultant corporate development role. Mr. Borrelly has over 25 years’ experience in corporate/business development as well as marketing and sales in the pharmaceutical (Ciba-Geigy, Novartis and Sanofi-Aventis) and biopharma industries. As President of Camargue Consulting, he specializes in development, evaluation and in-licensing of technologies, initiation of strategic alliances with multi-national corporate partners, and leading sales and marketing teams for commercial stage products.

“Nick’s extensive corporate development network and partnering expertise will be invaluable to creating significant shareholder value through attracting strong commercialization partners for our products. As Sernova is now exploring additional clinical applications of the Cell Pouch(TM), establishing corporate partners to help accelerate development has become an important part of our corporate strategy forward”, stated Dr. Philip Toleikis, Sernova’s President and CEO.

Mr. Borrelly said, “I am excited to work with Sernova’s CEO, Dr. Philip Toleikis, and his team to fully implement the strategic vision for its disruptive technologies for the cell-based treatment of chronic diseases.”

Nick’s past roles include Manager, Business Development - Licensing & Acquisitions with Sanofi Aventis Pharma Canada; Vice President, Business Development for MNLpharma (U.K.) Ltd.; and Vice President, Business Development for CV Technologies/Afexa Life Sciences Inc. As a Director with Nucleus BioScience Inc., he coordinated its amalgamation with Stratos BioSciences Inc. and Brightwave Technologies Inc. to create SNB Capital Corp., which subsequently took the biotherapeutics company Protox Therapeutics Inc. (now Sophiris Bio Inc; NASDAQ: SPHS) public in 2004. Nick is currently a member of the Board of Directors of Eternity Healthcare (OTCBB: ETAH), and Auxellence Health Corporation (CSE: AID).

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary local immune protection technologies.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

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Press Release Communiqué de presse - April 21, 2014 21 April, 2014

Sernova’s Cell Pouch™ Diabetes Clinical Trial Demonstrates Interim Safety and Biocompatibility


Sernova’s Cell Pouch with insulin-producing islets is safe and biocompatible in patients with unstable diabetes

Source: Sernova Corp FOR RELEASE April 22nd, 2014, 6:00 a.m. EDT LONDON, ONTARIO--(Marketwire – April 22nd, 2014) - Sernova Corp. (TSX-V: SVA), a clinical stage company developing medical technologies for the long-term treatment of chronic metabolic diseases including diabetes, blood disorders such as haemophilia and other diseases, today announced interim results in an ongoing type 1 diabetes human clinical trial with the Company’s Cell Pouch(TM).

Sernova’s human clinical trial is designed to assess the safety and efficacy of the Cell Pouch in subjects with unstable diabetes receiving an islet transplant. Interim study results in the first group of patients support that the implanted Cell Pouch, transplanted with insulin-producing islets is showing longer-term safety and biocompatibility with one of the patients beyond the 180 day time point.

Encouraging early results up to 30 days post-islet transplant were presented at the International Pancreas and Islet Transplantation Congress in September, 2013. These results showed after implantation under the skin, the Cell Pouch is safe and biocompatible. Following islet transplantation, the islets living within a natural tissue matrix were supported with a rich supply of blood vessels, similar to the pancreas. Of further importance, the islets were shown to make insulin, somatostatin and glucagon – key hormones in the control of blood sugar levels. The ongoing study is being conducted with Dr. James Shapiro as principal investigator at the University of Alberta Health Sciences Centre in Edmonton, Alberta.

"The fact that the Cell Pouch continues to exhibit both safety and biocompatibility in longer term follow-up is an important milestone in the early clinical testing of this device, and provides encouragement that human islets transplanted within the device may provide the opportunity to change the standard of care of patients with diabetes," said Dr. James Shapiro. “I look forward to the ongoing results of the investigation as the study progresses."

The study, entitled “A Phase I/II Study of the Safety and Efficacy of Sernova's Cell Pouch for Therapeutic Islet Transplantation,” is an open label, non- randomized, Phase I/II safety and efficacy study of up to 20 patients with type 1 diabetes undergoing allograft pancreatic islet transplantation. Patients who have met the enrolment criteria and provided informed consent are implanted with the Cell Pouch approximately 2-24 weeks prior to transplantation of donor human islets. To prevent islet graft rejection, the standard of care immunosuppressive regimen is provided.

The primary endpoint of the study is to assess the safety of the Sernova Cell Pouch in these patients just prior to islet transplantation, following islet transplantation and at various points during follow up. The secondary endpoint of the study, efficacy, is to determine the proportion of subjects implanted with the Cell Pouch and transplanted with islets who achieve and maintain insulin independence. Patient follow up occurs for a minimum of three years to assess long-term safety and efficacy.

“In the second half of 2014, we expect to provide further preliminary safety and efficacy data”, remarked Dr. James Shapiro.

"This interim update by Dr. Shapiro suggests we are making positive strides forward. The Cell Pouch could potentially be a game changer for patients suffering from this debilitating disease. Indeed, this is the result of years of hard work and dedication from our company's staff and collaborators," said Dr. Philip Toleikis, President and CEO of Sernova Corp. "We have developed the subcutaneous Cell Pouch for Sernova's first clinical application, insulin- dependent diabetes, as an alternative site for islet transplantation that may allow for safer, more efficient engraftment of islets and potential improved long-term insulin independence using a marginal islet mass. What adds further credence to the Cell Pouch’s mechanism of action is the application of the Cell Pouch for other clinical indications which Sernova is undertaking”, added Dr. Toleikis."

About the Cell Pouch The Cell Pouch is a proprietary, scalable, biocompatible medical device, that once implanted subcutaneously, incorporates with the patient’s tissue and microvessels. The Cell Pouch is contract manufactured (ISO13485) to meet international regulatory standards. Sernova’s research has demonstrated that when the Cell Pouch is inserted under the skin, it forms an ideal environment, rich in microvessels and tissue matrix for the placement and function of therapeutic cells. The Cell Pouch is currently being evaluated in clinical trials at the University of Alberta with Dr. James Shapiro as principal investigator in patients with type 1 diabetes receiving an islet transplant.

It has been shown in multiple preclinical studies to provide a safe environment for transplantation, as well as for the long-term survival and efficacy of therapeutic cells. Sernova's goals for the diabetes indication include making the Cell Pouch available to a wider group of patients than currently possible with intraportal delivery of islets. Sernova also plans to make the Cell Pouch available as a natural, improved site for non-primary-derived, insulin-secreting cells. This may enable long-term treatment in large numbers of patients with insulin-dependent diabetes without limitation to availability of donor-derived cells.

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch, an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required.

About Clinical Islet Transplantation Program Please view www.islet@ca for more information on the Clinical Islet Transplantation Program at the University of Alberta. For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Ray Matthews & Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

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Press Release Communiqué de presse - February 25, 2014 25 February, 2014

Sernova Announces Annual Meeting, Record Date and Adopts Advance Notice By-Law


FOR RELEASE February 26th, 2014, 6:00 a.m. EST LONDON, ONTARIO--(Marketwire – February 26th, 2014) - Sernova Corp. (TSX-V: SVA), a clinical stage company developing medical technologies for the long-term treatment of chronic debilitating metabolic diseases including diabetes and haemophilia is pleased to announce that it will hold an annual general and special meeting of shareholders (the “AGM”) on April 28, 2014. The record date for shareholders entitled to vote at the AGM is March 24, 2014. The Company also announces that the board of directors of the Company (the “Board”) has approved and adopted By-Law No. 3 of the Company, being a by-law relating to the nomination of directors of the Company (the “Advance Notice By-Law) which requires that advance notice be provided to the Company in circumstances where nominations of persons for election to the Board are made by shareholders of the Company other than pursuant to: (i) a requisition of a meeting of shareholders made pursuant to the provisions of the Canada Business Corporations Act; or (ii) a shareholder proposal made pursuant to the provisions of such Act.

“We feel the Advance Notice By-Law is an important corporate governance tool that will ensure Sernova’s shareholders are treated fairly in being provided advanced notice of information in connection with the nomination of directors,” said Dr. Philip Toleikis, President and CEO. The Advance Notice By-law is similar to the advance notice by-laws adopted by many other Canadian public companies. The purpose is to foster a variety of interests of the shareholders and the Company by ensuring that all shareholders, including those participating in a meeting by proxy rather than in person, receive adequate notice of the nominations to be considered at a meeting and can thereby exercise their voting rights in an informed manner. In addition, the Advance Notice By-Law should assist in facilitating an orderly and efficient meeting process, provides shareholders, directors and management of the Company with a clear framework for nominating directors. Among other things, the Advance Notice by-Law fixes a deadline by which shareholders must submit director nominations to the Company prior to any meeting of shareholders and sets forth the minimum information that a shareholder must include in the notice to the Company for the notice to be in proper written form.

In the case of an annual meeting of shareholders, notice to the Company must be made not less than 30 nor more than 65 days prior to the date of the annual meeting; provided, however that in the event the annual meeting is to be held on a date that is less than 40 days after the date on which the first public announcement of the date of the annual meeting was made, notice may be made not later than the close of business on the 10th day following such public announcement.

In the case of a special meeting of shareholders (which is not also an annual meeting), notice to the Company must be made not later than the close of business on the 15th day following the day on which the first public announcement of the date of the special meeting was made.

The Advance Notice By-Law has been approved and adopted by the Board and is effective immediately. Shareholders will be asked to ratify and confirm the Advanced Notice By-Law at the AGM. A copy of the By-Law Amendments will be provided in the Management Information Circular, which will be filed under the Company’s profile at www.sedar.com.

For purposes of the AGM, in accordance with the terms of the Advance Notice By-Law, notice of nominations of persons for election to the Board at the AGM must be made by March 28, 2014 and be sent to the following email address of the Chief Executive Officer of the Company: Philip.toleikis@sernova.com

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell PouchTM, an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technology, SertolinTM. For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Cathy Steiner, CFO Tel: (416) 566-7870 cathy.steiner@sernova.com

Ray Matthews & Associates Ray Matthews Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - February 10, 2014 10 February, 2014

Frank Holler Joins Sernova’s Board of Directors


Experienced Biotech Entrepreneur and Investor to Bring Strategic Growth Expertise to Sernova

Source: Sernova Corp FOR RELEASE February 11th, 2014, 6:00 a.m. EST LONDON, ONTARIO--(Marketwire – February 11th, 2014) - Sernova Corp. (TSX-V: SVA), a clinical stage company developing medical technologies for the long-term treatment of chronic debilitating metabolic diseases including diabetes, blood disorders such as haemophilia and other diseases, today announced the appointment of Mr. Frank Holler to its Board of Directors. A Vancouver-based entrepreneur and investor, Holler brings 25 years of success-driven experience in the biopharma and technology sectors to Sernova’s board. He has been directly involved in the founding and development of some of Canada’s most successful biopharma companies including ID Biomedical, Angiotech Pharmaceuticals and Xenon Pharmaceuticals.

“Frank possesses the ideal combination of coveted bio-science experience and strategic relationships with institutions and pharma to guide Sernova’s strategic advancement,” stated Dr. George Adams, Sernova’s Board Chair.

“I am pleased to be joining the board of Sernova,” said Mr. Holler. “Sernova’s CEO, Dr. Philip Toleikis is a former Angiotech colleague and I am looking forward to working with him and the Sernova team as we advance Sernova’s therapeutic cell-based product development programs and drive value for shareholders.”

Mr. Holler previously served as President & CEO of Xenon Pharmaceuticals, Inc., a genetics-based drug development company focused on the treatment of rare inherited medical conditions, President & CEO of ID Biomedical Corporation, a vaccine development company sold to GlaxoSmithKline in 2005, and was a founding director of Angiotech Pharmaceuticals, a TSX/NASDAQ-listed biotechnology company. He was also an investment banker with Merrill Lynch Canada and Wood Gundy, Inc. (now CIBC World Markets) and former director of the British Columbia Biotechnology Association (now LifeSciences BC), and in 2003 received the BC Biotech Award for Vision and Leadership. “Frank’s extensive industry experience, capital markets expertise and strategic insights will be very helpful as Sernova continues to advance its programs,” said Dr. Philip Toleikis, President and CEO of Sernova. “In particular, I believe his background in corporate finance, strategic partnering and M&A will be a good fit for Sernova as we continue to build out the Company’s leading position in regenerative medicine.”

Sernova also announces that it has granted an aggregate of 150,000 incentive stock options on February 11, 2014 to certain directors of the Company to purchase common shares in the capital stock of the Company subject to approval of the TSX Venture Exchange. Each option entitles the holder to purchase one common share of the Company at an exercise price of $0.15, for a period of 5 years, in accordance with the provisions of the Sernova Stock Option Plan.

About Sernova Sernova Corp is a clinical stage regenerative medicinecompany developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technology, Sertolin(TM).

About the Cell Pouch(TM) The Cell Pouch(TM) is a proprietary scalable biocompatible medical device, contract manufactured (ISO13485) to meet international regulatory standards. It is inserted under the skin, and forms an ideal environment, rich in microvessels and tissue matrix for the placement and function of therapeutic cells. The Cell Pouch(TM) is currently being evaluated in clinical trials at the University of Alberta with Dr. James Shapiro as principal investigator in patients with Type 1 diabetes receiving an islet transplant.

About Sertolin(TM) Sertoli cells when co-localized with donor therapeutic cells release protective factors that can provide a non-toxic, immune-protected environment that may reduce or eliminate the need for daily anti-rejection drugs that currently must be used by patients with transplanted tissues and organs. Sernova is currently conducting preclinical studies to optimize sertoli cells and islets within the Cell Pouch(TM) through a NRC-IRAP contribution agreement provided by the Government of Canada.

About Clinical Islet Transplantation Program Please view www.islet@ca for more information on the Clinical Islet Transplantation Program at the University of Alberta.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Cathy Steiner, CPA CA MSc MBA, CFO Tel: (416) 566-7870 cathy.steiner@sernova.com

Ray Matthews & Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 Tel: (604) 818-7778 www.raymatthews.ca

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - January 30, 2014 30 January, 2014

Sernova Announces Appointment of Cathy Steiner as CFO


Source: Sernova Corp FOR RELEASE January 31st, 2014, 6:00 a.m. EST LONDON, ONTARIO--(Marketwire – Jan. 31st, 2014) - Sernova Corp. (TSX-V: SVA), today announced that Ms. Cathy R. Steiner, CPA CA MSc MBA has joined the Company as Chief Financial Officer.

Ms. Steiner is an industry veteran with over 20 years of experience working with healthcare companies as an investment banker, financial and capital markets advisor, and management consultant. Prior to joining Sernova, Ms. Steiner was Managing Director of Nucleus GC, an advisory services boutique specializing in the healthcare and life sciences sector. In this capacity, she advised healthcare clients at all stages of development on financings, mergers and acquisitions, business development, and growth strategy.

Previously she held the positions of Executive Director, Healthcare Investment Banking for CIBC World Markets, and Vice President, Healthcare Investment Banking for Yorkton Securities, where she was instrumental in raising over $1 billion in funding for Canadian-based companies, and in mergers and acquisitions worth in excess of $2 billion. Earlier, Ms. Steiner was Senior Tax Specialist at Deloitte.

“We are delighted to be bringing Cathy on board as Sernova’s CFO,” stated Dr. Philip Toleikis, President and CEO of Sernova. “Given her deep capital markets expertise as well as her extensive experience planning and closing successful transactions for healthcare companies, we are confident that she will make a great contribution to strengthening our financial position and advancing our corporate development.”

Sernova wishes to thank Mr. Bill Smethurst, the outgoing CFO, for his service to the Company.

Sernova also announces that it has granted an aggregate of 2,910,000 incentive stock options on January 27th, 2014 to certain directors, officers, employees and consultants of the Company to purchase common shares in the capital stock of the Company subject to approval of the TSX Venture Exchange. Each option entitles the holder to purchase one common share of the Company at an exercise price of $0.15, for a period of 5 years, in accordance with the provisions of the Sernova Stock Option Plan.

About Sernova Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technology, Sertolin(TM).

About the Cell Pouch(TM) The Cell Pouch(TM) is a proprietary scalable biocompatible medical device, contract manufactured (ISO13485) to meet international regulatory standards. It is inserted under the skin, and forms an ideal environment, rich in microvessels and tissue matrix for the placement and function of therapeutic cells. The Cell Pouch(TM) is currently being evaluated in clinical trials at the University of Alberta with Dr. James Shapiro as principal investigator in patients with Type 1 diabetes receiving an islet transplant.

About Sertolin(TM) Sertoli cells when co-localized with donor therapeutic cells release protective factors that can provide a non-toxic, immune-protected environment that may reduce or eliminate the need for daily anti-rejection drugs that currently must be used by patients with transplanted tissues and organs. Sernova is currently conducting preclinical studies to optimize sertoli cells and islets within the Cell Pouch(TM) through a NRC-IRAP contribution agreement provided by the Government of Canada.

About Clinical Islet Transplantation Program Please view www.islet@ca for more information on the Clinical Islet Transplantation Program at the University of Alberta.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 philip.toleikis@sernova.com info@sernova.com www.sernova.com

Cathy Steiner, CPA CA MSc MBA, CFO Tel: (416) 566-7870 cathy.steiner@sernova.com

Ray Matthews and Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 www.raymatthews.ca 604-818-7778

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - January 12, 2014 12 January, 2014

Sernova to Present Company and Clinical Update at Biotech Showcase™ Healthcare Conference in San Francisco


LONDON, ONTARIO--(Marketwire – Jan. 13, 2014) - Sernova Corp (TSX-V: SVA), today announced that Dr. Philip Toleikis, Ph.D., the company’s Chief Executive Officer will present an update on the company’s business strategy and clinical study at the Biotech Showcase(TM) healthcare conference in San Francisco, CA. This important conference brings together global industry leaders, emerging companies and members of the investment community. Sernova is currently conducting a Phase I/II clinical trial of its Cell Pouch(TM) at the University of Alberta in patients with Type 1 diabetes who are receiving an islet transplant with Dr. James Shapiro as principal investigator.

Details of Sernova Corp’s presentation are as follows: Event: Biotech Showcase(TM) 2014 Conference Date: January 14, 2014 Time: 4:30 P.M. PST Location: Parc 55 Wyndham SF Union Sq. Hotel; 3(rd) Floor Track D Powell

“We are presenting Sernova’s strategic approach and product development advancements during the industry’s largest conglomerate of annual healthcare investor conferences and arguably the most important healthcare investment symposia in the industry,” remarked Dr. Philip Toleikis, President and CEO.

“With Sernova anticipating the release of Phase I/II interim clinical efficacy data in 2014, as well as advancements in our other programs and collaborations, this is an excellent opportunity to highlight the company’s progress and future direction,” added Dr. Toleikis.

About the Biotech Showcase(TM) (Innovation –Opportunity – Collaboration)

Co-produced by Demy-Colton Life Science Advisors and EBD Group, Biotech Showcase is an investor and partnering conference devoted to providing private and public biotechnology and life sciences companies an opportunity to present to, and meet with, investors and pharmaceutical executives during the course of one of the industry’s largest annual healthcare investor conferences. Now in its sixth year, Biotech Showcase is expected to attract upwards of 1,500 attendees.

About Sernova

Sernova Corp is a clinical stage regenerative medicine company developing medical technologies for the treatment of chronic debilitating metabolic diseases such as diabetes, blood disorders including haemophilia and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. Sernova is developing the Cell Pouch(TM), an implantable medical device for therapeutic cells (donor, xenogeneic or stem cells) which then release proteins and/or hormones as required. The therapeutic cells are protected from immune attack by Sernova’s proprietary technology, Sertolin(TM).

About the Cell Pouch(TM)

The Cell Pouch(TM) is a proprietary scalable biocompatible medical device, contract manufactured (ISO13485) to meet international regulatory standards. It is inserted under the skin, and forms an ideal environment, rich in microvessels and tissue matrix for the placement and function of therapeutic cells. The Cell Pouch(TM) is currently being evaluated in clinical trials at the University of Alberta with Dr. James Shapiro as principal investigator in patients with Type 1 diabetes receiving an islet transplant.

About Sertolin(TM)

Sertoli cells when co-localized with donor therapeutic cells release protective factors that can provide a non-toxic, immune-protected environment that may reduce or eliminate the need for daily anti-rejection drugs that currently must be used by patients with transplanted tissues and organs. Sernova is currently conducting preclinical studies to optimize sertoli cells and islets within the Cell Pouch(TM) through a NRC-IRAP contribution agreement provided by the Government of Canada.

About Clinical Islet Transplantation Program

Please view www.islet@ca for more information on the Clinical Islet Transplantation Program at the University of Alberta. For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Ray Matthews and Associates Suite 601-128 West Cordova Street, Vancouver, BC V6B 0E6 www.raymatthews.ca 604.818.7778

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.