2012 Press Releases Communiqués de presse

December 3, 2012 3 December, 2012

Sernova's Novel Method Evaluates Islets Prior to Transplantation and Predicts Their Ability to Reverse Diabetes Post Transplantation

September 4, 2012 4 September, 2012

Sernova to Present at Rodman & Renshaw Annual Global Investment Conference

August 15, 2012 15 August, 2012

World First - Islet Transplant Into Man Using Sernova's Cell Pouch™ For Treatment Of Diabetes

June 6, 2012 6 June, 2012

Sernova Announces Exercise of Warrants

May 2, 2012 2 May, 2012

Sernova Receives Health Canada Approval to Initiate Human Clinical Trials of its Cell Pouch ™

April 30, 2012 30 April, 2012

Sernova Announces Appointments to Board of Directors

April 18, 2012 18 April, 2012

Sernova Receives Ethics Board Approval To Initiate First Clinical Study Of Cell Pouch™

April 3, 2012 3 April, 2012

Sernova Completes $3.6M Non-Brokered Private Placement

February 29, 2012 29 February, 2012

Sernova Completes First Tranche Of Non-Brokered Private Placement

February 16, 2012 16 February, 2012

Sernova Announces $3.5 Million Private Placement

January 19, 2012 19 January, 2012

Sernova Receives Patent Allowance in Japan

January 9, 2012 9 January, 2012

Sernova to Present Company and Clinical Update at Biotech Showcase™ San Francisco

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Press Release Communiqué de presse - December 03, 2012 3 December, 2012

Sernova's Novel Method Evaluates Islets Prior to Transplantation and Predicts Their Ability to Reverse Diabetes Post Transplantation


-Reseach findings published in journal Cell Transplantation-

Source: Sernova Corp LONDON, ONTARIO (Marketwire -- December 4, 2012) -- Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced the publication of a novel, sensitive and rapid method developed at Sernova to evaluate insulin-producing donor islets prior to transplant as a predictor of which transplants are most likely to reverse diabetes. Research findings were published in the journal Cell Transplantation.

"The publication of Sernova's novel method of evaluating islets further demonstrates our commitment in improving the treatment of patients with diabetes receiving islet transplantation," said Dr. Philip Toleikis, President and CEO of Sernova Corp. "Coupled with the advancement of our Phase I/II clinical study of our Cell Pouch(TM) for the treatment of Type-1 diabetes, Sernova is in line with its vision to advance technologies that will improve the lives of people living with chronic diseases such as diabetes."

A major consideration for any islet transplant is the quality or health of the islets being placed into the patient to treat insulin-dependent diabetes. This can be influenced by such factors as the condition of the donor, preservation technique and time to transplantation as well as factors involved in the isolation of the islets from the pancreas. A rapid pre-transplant predictive measure of islet quality would be beneficial to transplant surgeons to select the best islet preparations for transplantation.

The study compared the new method with various standard techniques for measuring islet function prior to transplantation, including among others insulin secretion following glucose stimulation, islet viability, presence of high energy metabolic molecules and factors such as islet size, number and volume of islets.

The predictor of islet graft function considers both the effects of islet oxygen consumption and islet size (islet index). When these two measures were combined and tested in mature porcine islets, the results showed establishment of a highly statistically significant predictor of future graft function (diabetes reversal) following transplantation into small animals. Importantly, the study also established an effective oxygen consumption/islet index threshold value of diabetes reversal. The study found that none of the other measures of pre-transplant islet function predicted reversal of diabetes in animals. Sernova is evaluating this technique in humans using the standard portal vein delivery and in the current Phase I/II study of the Cell Pouch(TM) for islet transplantation.

These important research findings have been published as a "fast track article" in an online publication of the peer reviewed journal, Cell Transplantation, in advance of print and can be found at the following address: http://www.ingentaconnect.com/content/cog/ct/pr e- prints/ct0577pepper.

About The Cell Pouch(TM)

The Cell Pouch(TM) is a proprietary medical device that, following subcutaneous implantation, incorporates with tissue and microvessels forming a natural environment for transplantation of therapeutic cells. Multiple preclinical studies demonstrated the Cell Pouch(TM) to provide a safe environment for transplantation, as well as long- term efficacy of therapeutic cells. Sernova is currently conducting a Phase I/II human clinical study in patients with diabetes who will receive donor islets into the implanted Cell Pouch(TM) to assess safety and efficacy. Sernova's goals for the Cell Pouch(TM) for diabetes include providing a safe and natural site for islets to significantly increase the number of patients currently treated with intraportal delivery of donor islets and to provide a safe environment for virtually unlimited available sources of insulin-secreting cells such as insulin- producing stem cells and xenogeneic cells. This vision combined with local anti-rejection protection of the cells could enable millions of patients with insulin-dependent diabetes to be treated without limitation to availability of cells.

About Sernova

Sernova Corp. is a clinical stage health-sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin-dependent diabetes, using the novel Cell Pouch System(TM) for transplantation and long- term survival of therapeutic cells and its patented Sertolin(TM) cell technology which can provide an immune-protected local environment for therapeutic cells.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - September 04, 2012 4 September, 2012

Sernova to Present at Rodman & Renshaw Annual Global Investment Conference


LONDON, ONTARIO (Marketwire - September 4, 2012) - Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced that Dr. Philip Toleikis, President and CEO, will present at the Rodman & Renshaw Annual Global Investment Conference (14th Annual Healthcare Conference) at 4:05 p.m. EDT, September 11th, in the Starlight Center Salon at The Waldorf Astoria Hotel in New York City.

"The invitation to Sernova to present at the New York Rodman and Renshaw Conference provides the Company with an excellent opportunity to gain further exposure to investors and analysts," said Philip Toleikis, President and CEO of Sernova Corp.

Dr. Toleikis will provide an overview of the Company's business strategy and the ongoing Phase I/II clinical trial of the Cell Pouch(TM) with insulin-producing islets in patients with Type-1 diabetes.

About The Cell Pouch(TM)

The Cell Pouch(TM) is a proprietary medical device that, following subcutaneous implantation, incorporates with tissue and microvessels forming a natural environment for transplantation of therapeutic cells. Multiple preclinical studies demonstrated the Cell Pouch(TM) to provide a safe environment for transplantation, as well as long- term efficacy of therapeutic cells. Sernova is currently conducting a Phase I/II human clinical study of the Cell Pouch(TM) with insulin-producing islets in patients with Type-1 diabetes at the University of Alberta with Dr. James Shapiro as principal investigator. Sernova's goals for the Cell Pouch(TM) for diabetes include providing a safe and natural site for islets to significantly increase the number of patients currently treated with intraportal delivery of donor islets and to provide a safe environment for virtually unlimited available sources of insulin- secreting cells such as insulin-producing stem cells and xenogeneic cells. This vision combined with local anti- rejection protection of the cells could enable millions of patients with insulin-dependent diabetes to be treated without limitation to availability of cells.

About Sernova

Sernova Corp. is a clinical stage health-sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin-dependent diabetes, using the novel Cell Pouch System(TM) for transplantation and long- term survival of therapeutic cells and its patented Sertolin(TM) cell technology which can provide an immune-protected local environment for therapeutic cells.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - August 15, 2012 15 August, 2012

World First - Islet Transplant Into Man Using Sernova's Cell Pouch™ For Treatment Of Diabetes


-Company to Host Conference Call at 9 a.m. EDT, Today, Aug. 16, to Discuss Clinical and Business Developments-

Source: Sernova Corp

LONDON, ONTARIO and EDMONTON, ALBERTA (Marketwire -- August 16, 2012) -- Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) and the University of Alberta today announced the treatment of the first patient with insulin- producing islets transplanted into Sernova's Cell Pouch(TM) in a Phase I/II clinical study to treat Type-1 diabetes led by Dr. James Shapiro, Professor of Surgery and Medicine, University of Alberta and Director, Clinical Islet Transplant Program. Sernova will host a conference call at 9 a.m. EDT, today, Aug. 16, 2012, to discuss the company's clinical and business developments.

"The Sernova Cell Pouch(TM) implantation and transplantation processes are simple, rapid minimally invasive procedures, conducted on an outpatient basis under local anesthesia," said Dr. Shapiro. "This offers substantial potential benefit over the Edmonton protocol and the ease of use provides an opportunity for the Cell Pouch(TM) to become the standard of care for people with diabetes if it proves to be effective in these initial trials."

The objectives of the human clinical trial are to assess the safety and efficacy of the Cell Pouch(TM) with transplanted islets in up to 20 patients with Type- 1 diabetes. The study is sponsored by Sernova Corp and the University of Alberta. In the study, patients who have met the enrolment criteria and provided informed consent are implanted with the Cell Pouch(TM) prior to transplantation of donor human islets. To prevent islet graft rejection, patients in this study are treated with the best in class standard of care immunosuppression protocol. Interim analysis of the data from this clinical study is expected during H1, 2013. Further information on the trial may be found at www.clinicaltrials.gov (Identifier: NCT01652911).

"The Cell Pouch(TM) is a breakthrough technology which has the potential to significantly improve the lives of people living with chronic diseases such as diabetes," said Philip Toleikis, Ph.D., President and CEO of Sernova Corp. "Supported by Sernova's strong preclinical results, the treatment of patients in this clinical trial of the Cell Pouch(TM) further advances our vision for the future of providing millions of diabetic patients with the Cell Pouch(TM), and an unlimited source of insulin- producing cells protected with a local anti-rejection technology."

Conference Call

The conference call to discuss Sernova's clinical and business developments may be accessed by dialing 866- 532-1852 for domestic callers and +443-842- 7644 for international callers. Please specify to the operator that you would like to join the "Sernova conference call" or "conference ID: 21155379."

About The Cell Pouch(TM)

The Cell Pouch(TM) is a proprietary medical device that, following subcutaneous implantation, incorporates with tissue and microvessels forming a natural environment for transplantation of therapeutic cells. Multiple preclinical studies demonstrated the Cell Pouch(TM) to provide a safe environment for transplantation, as well as long- term efficacy of therapeutic cells. Sernova's goals for the Cell Pouch(TM) for diabetes include providing a safe and natural site for islets to significantly increase the number of patients currently treated with intraportal delivery of donor islets and to provide a safe environment for virtually unlimited available sources of insulin-secreting cells such as insulin-producing stem cells and xenogeneic cells. This vision combined with local anti-rejection protection of the cells could enable millions of patients with insulin- dependent diabetes to be treated without limitation to availability of cells.

About Sernova

Sernova Corp. is a clinical stage health-sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin-dependent diabetes, using the novel Cell Pouch System(TM) for transplantation and long- term survival of therapeutic cells and its patented Sertolin(TM) cell technology which can provide an immune-protected local environment for therapeutic cells.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Dr. James Shapiro MD PhD FRCS Professor of Surgery and Medicine, University of Alberta Director, Clinical Islet Transplant Program Tel: (780) 407-7330

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - June 06, 2012 6 June, 2012

Sernova Announces Exercise of Warrants


LONDON, ONTARIO - June 6, 2012 - Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA) is pleased to announce that, since mid-April, it has received gross proceeds of $772,182 on exercise of 3,878,277 common share purchase warrants, of which 3,808,814 were exercisable at a price of $0.20 per share and 69,463 warrants were exercisable at a price of $0.15 per share.

The warrants were issued in connection with private placements which closed between 2009 and 2011. The funds will be used to support the ongoing Phase I/II human clinical trial of the Cell Pouch(TM) and for general working capital purposes.

"This demonstration of support from our shareholders has strengthened Sernova's working capital position and shows continued excitement for the direction of the Company as we develop our product platform technologies," stated Dr. Philip Toleikis, President and CEO of Sernova.

About Sernova

Sernova Corp. is a Canadian-based, health- sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin- dependent diabetes, using the novel Cell Pouch System(TM), a medical device for transplantation and long-term efficacy of therapeutic cells and its patented Sertolin(TM) cell technology which provides local immune protection of therapeutic cells.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - May 02, 2012 2 May, 2012

Sernova Receives Health Canada Approval to Initiate Human Clinical Trials of its Cell Pouch ™


-Patients with insulin-dependent diabetes to be treated with Sernova's subcutaneous Cell Pouch (TM) and insulin- producing islets-

Source: Sernova Corp

LONDON, ONTARIO--(Marketwire - May 2, 2012) - Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced it received Health Canada Approval to conduct a human clinical trial assessing both the safety and efficacy of Sernova's Cell Pouch(TM) with transplanted insulin-producing islets in patients with insulin-dependent diabetes. The study will be conducted in collaboration with Dr. James Shapiro at the University of Alberta Health Science Centre in Edmonton.

"Sernova's compelling pre-clinical results provide optimism that the Cell Pouch(TM) has the potential to change the standard of care of patients with diabetes receiving islet transplantation," said Dr. James Shapiro, principal investigator of the study. "I am excited to begin enrolment of patients in this ground breaking clinical study to evaluate the Cell Pouch(TM) in humans."

The study, entitled "A Phase I/II Study of the Safety and Efficacy of Sernova's Cell Pouch(TM) for Therapeutic Islet Transplantation," is an open label, non- randomized, single-arm, Phase I/II safety and efficacy study of up to 20 patients with insulin-dependent diabetes undergoing allograft pancreatic islet transplantation.

In this study, patients who have met the enrolment criteria and provided informed consent will be implanted with the Cell Pouch(TM) approximately 2-12 weeks prior to transplantation of donor human islets. To prevent islet graft rejection, patients will be treated with the standard immunosuppressive regimen.

The primary endpoint of the study is to assess the safety of the Sernova Cell Pouch(TM) in adult participants with Type-1 diabetes receiving islet transplantation for the first time. This endpoint will be assessed just prior to islet transplantation and one month thereafter.

The secondary endpoint of the study is to determine the proportion of subjects implanted with the Cell Pouch(TM) and transplanted with islets who achieve and maintain insulin independence as measured three months post-final islet transplantation.

In addition, the study will provide preliminary data on the efficacy of the Cell Pouch(TM) to maintain adequate immunological protection against both allo- and autoimmunity of islet transplant recipients.

Following assessment of primary and secondary endpoints, patients will be followed for a minimum of three years to assess long-term safety and efficacy of the Cell Pouch(TM). It should also be noted that the study allows for interim analysis of the data at various study time points.

"The initiation of this study marks a significant milestone for Sernova, and is the result of years of hard work and dedication from our company's staff and collaborators," said Dr. Philip Toleikis, President and CEO of Sernova Corp. "We have developed the subcutaneous Cell Pouch(TM) for Sernova's first clinical application, insulin- dependent diabetes, as an alternative site for islet transplantation that may allow for safer, more efficient engraftment of islets and potential improved long-term insulin independence using a marginal islet mass. We are pleased to have Dr. Shapiro and his team conduct this study at this world class institute for islet transplantation."

The Cell Pouch(TM) is a proprietary medical device that, once implanted subcutaneously, incorporates with tissue and microvessels. It has been shown in multiple preclinical studies to provide a safe environment for transplantation, as well as long-term survival and efficacy of therapeutic cells. Sernova's goals for the diabetes indication include making the Cell Pouch(TM) available to a wider group of patients than currently possible with intraportal delivery of islets. Sernova also plans to make the Cell Pouch(TM) available as a natural, improved site for non- primary- derived, insulin-secreting cells for long-term function to enable large numbers of patients with insulin- dependent diabetes to be treated without limitation to availability of cells.

About Sernova

Sernova Corp. is a clinical stage health-sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin-dependent diabetes, using the novel Cell Pouch System(TM) for transplantation and long- term survival of therapeutic cells and its patented Sertolin(TM) cell technology which can provide an immune-protected local environment for therapeutic cells.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - April 30, 2012 30 April, 2012

Sernova Announces Appointments to Board of Directors


LONDON, ONTARIO - (Marketwire - April 30, 2012) - Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced that at the annual general meeting held April 19, 2012, Bruce Weber and James Parsons were elected to the Corporation's Board of Directors.

"The appointment of Mr. Weber and Mr. Parsons strengthens Sernova's Board from a perspective in the international clinical, regulatory and corporate finance arenas," said Dr. George Adams, Chairman of the Board of Directors of Sernova. "With Sernova's upcoming launch of its first in man Canadian clinical trial of the Cell Pouch(TM), the company is strategically focused on clinical validations and partnerships to advance its products. The board now has seasoned Directors with operational and transactional experience to properly govern and guide the Company."

In his distinguished career, Mr. Weber is currently Vice President, Clinical, Regulatory and Quality Assurance at Innovia LLC, since 2004. Prior to this appointment, Mr. Weber held a number of senior management positions including Vice President of Product Assurance at Syntheon LLC from 1998 to 2004, Vice President, Product Assurance at Corvita Corporation from 1989 to 1998, and Corporate Quality Assurance Manager at Organon Teknika from 1987 to 1988. He also held positions as Director of Manufacturing at BioNexus, Senior Regulatory Affairs Associate at Cordis Corporation, Production Manager at C.R. Bard, Inc. and Quality Control Manager at Cordis Dow Corporation.

Mr. Parsons is currently Vice President Finance and Corporate Secretary at Diamedica, Inc. since 2010 and also is Chief Financial Officer of Stem Cell Therapeutics Corp. since August 2011. Prior to these positions Mr. Parsons was Chief Financial Officer and Corporate Secretary of Amorfix Life Sciences, Ltd. from 2005 to 2010. Mr. Parsons also holds senior positions with a number of biotechnology companies and advises a number of early-stage companies within the industry. Mr. Parsons has over twenty years of experience working with Board of Directors and Audit Committees and has extensive experience in establishing and developing committee policies, mandates and governance processes. Mr. Parsons has secured approximately $100M of financing during his career and has advised and assisted on over $200M of product out-licensing, research agreements and in-licensing deals.

In connection with the appointment of Mr. Weber and Mr. Parsons, they were each granted 250,000 options on April 19, 2012 to purchase shares at an exercise price of $0.18 for a period of 5 years in accordance with the provisions of the Sernova stock option plan.

About Sernova

Sernova Corp. is a Canadian-based, health- sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin- dependent diabetes, using the novel Cell Pouch System(TM) and its patented Sertolin(TM) cell technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - April 18, 2012 18 April, 2012

Sernova Receives Ethics Board Approval To Initiate First Clinical Study Of Cell Pouch™


-Company Completes Manufacture and Release of Cell Pouch(TM) Clinical Product-

Source: Sernova Corp

LONDON, ONTARIO--(Marketwire -- April 19, 2012) -- Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced it has received the University of Alberta hospital ethics board approval to initiate the first clinical study of the Cell Pouch(TM) pending Health Canada clearance. The company has also completed the manufacture and release of the Cell Pouch(TM) clinical product from its contract manufacturer, Moog Medical Devices Group of Buffalo, New York.

"Completion of the manufacture and release of the Cell Pouch(TM) for clinical evaluation demonstrates that the Cell Pouch(TM) can be manufactured to tight specifications and under strict regulatory guidelines," said Dr. Philip Toleikis, President and CEO of Sernova. "The final step to initiate the clinical study is Health Canada clearance of our submission, which is currently under review."

The process development and the manufacturing of the Cell Pouch(TM) at Moog Medical Devices Group of Buffalo, New York, is conducted in accordance with Moog's Quality System, which is compliant to ISO 13485:2003, MDD 93/42/EEC, US FDA Quality System Regulations (QSR) 21 CFR 820, and Canadian Medical Device Regulation (CMDR). The sterilization of the Cell Pouch(TM) has been performed in accordance to ANSI/AAMI/ISO 11135-1: 2007 -- Sterilization of Health Care Products -- Ethylene Oxide -- Part 1: Requirements for Development, Validation, and Routine Control of a Sterilization Process for Medical Devices, and associated technical information reports. As a scalable product, the process developed will enable Moog to manufacture the Cell Pouch(TM) to the size and number required for any future clinical applications.

The upcoming clinical trial of the Cell Pouch (TM) is a Phase I/II safety and efficacy study of up to 20 patients with diabetes undergoing allograft pancreatic islet transplantation. The study is to be conducted at the University of Alberta under the direction of Dr. James Shapiro as principal investigator.

Sernova also announced that it has granted incentive stock options (the "Options") to purchase up to 2,365,000 common shares of the Company to directors, officers, employees and consultants of the Company, of which 1,975,000 options were granted to directors and officers of the Company. The Options are subject to the terms of the Company's stock option plan and are exercisable for a period of five years at $0.18 per share.

Furthermore, Mr. Hans Mader will not be standing for reelection to the Sernova board. "I can speak for all the Directors in thanking Hans for his expert advice and gracious presence on the Board", said Dr. George Adams, Chairman.

About Sernova

Sernova Corp. is a clinical stage health-sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin-dependent diabetes, using the novel Cell Pouch System(TM) and its patented Sertolin(TM) cell technology.

For further information contact: Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements.

Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - April 03, 2012 3 April, 2012

Sernova Completes $3.6M Non-Brokered Private Placement


THIS NEWS RELEASE IS NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES

LONDON, ONTARIO--(Marketwire -- April 3, 2012) -- Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) today announced that it has completed the non-brokered private placement (the "Offering"), previously announced on February 12, 2012, and the over subscription of which was announced on February 28, 2012, for a total of 20,167,332 units of the Company (the "Units") at a price of $0.18 per Unit, raising approximately $3,630,120 in gross proceeds.

"We plan to utilize the proceeds from this private placement to initiate the first-in-world clinical study of the Cell Pouch(TM) in patients with diabetes who are undergoing transplantation of insulin producing islets, pending approval by Health Canada," said Dr. Philip Toleikis, President and CEO of Sernova. "Dr. James Shapiro will act as the principal investigator of this study at the University of Alberta in Edmonton."

The Company completed the Offering in two tranches -- 772,222 Units were issued in the second tranche on March 30, 2012 and 19,395,110 Units were issued in the first tranche on February 28, 2012.

Each Unit consists of one common share of the Company (a "Share") and one common share purchase warrant (a "Warrant"). Each Warrant entitles the holder thereof to purchase one Share (a "Warrant Share") for a period of three years, at a price of $0.20 per Warrant Share in the first year and at a price of $0.35 per Warrant Share in the second and third years.

The proceeds from the Offering will be used by Sernova for research and development of its proprietary Cell Pouch System(TM), and, in particular, to fund the upcoming first- in-man clinical trial for patients with diabetes receiving an islet transplant, and for general and administrative expenses.

All securities issued in connection with this second tranche of the Offering are subject to a statutory hold period of four month plus one day from the date of completion of the first tranche of the Offering, expiring July 31, 2012, in accordance with applicable securities legislation.

About Sernova

Sernova Corp. is a Canadian-based, health- sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin- dependent diabetes, using the novel Cell Pouch System(TM) and its patented Sertolin(TM) cell technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

The securities offered have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or any applicable exemption from the registration requirement of such Act. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful.

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Press Release Communiqué de presse - February 29, 2012 29 February, 2012

Sernova Completes First Tranche Of Non-Brokered Private Placement


LONDON, ONTARIO--(Marketwire -- February 29, 2012) -- Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE: SVA - News) is pleased to announce that it has closed the first tranche of the non-brokered private placement (the "Offering") announced on February 12, 2012. The Offering, which was previously announced as being up to 19,444,444 units of the Company ("Units") at a price of $0.18 per Unit for gross proceeds of approximately $3.5 million, was increased by $130,120 to accommodate oversubscriptions.

In this first tranche of the Offering, the Company has raised gross proceeds of $3,491,120 through the issuance of 19,395,100 Units. Each Unit consists of one common share of the Company (a "Share") and one common share purchase warrant (a "Warrant"). Each Warrant entitles the holder thereof to purchase one Share (a "Warrant Share") for a period of three years, at a price of $0.20 per Warrant Share in the first year and at a price of $0.35 per Warrant Share in the second and third years. The Company intends to complete a secondary closing of up to 772,222 Units.

The proceeds from the Offering will be used by Sernova for research and development of its proprietary Cell Pouch SystemTM , and, in particular, to fund the upcoming first in man clinical trial for patients with diabetes receiving an islet transplant, and for general and administrative expenses.

All securities issued in connection with this first tranche of the Offering are subject to a statutory hold period of four month plus one day from the date of completion of the first tranche of the Offering, expiring June 29, 2012, in accordance with applicable securities legislation.

About Sernova

Sernova Corp. is a Canadian-based, health- sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin- dependent diabetes, using the novel Cell Pouch SystemTM and its patented SertolinTM cell technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

The securities offered have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or any applicable exemption from the registration requirement of such Act. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful.

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Press Release Communiqué de presse - February 16, 2012 16 February, 2012

Sernova Announces $3.5 Million Private Placement


$2.5M SECURED

THIS NEWS RELEASE IS NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES

LONDON, ONTARIO - (Marketwire - February 16, 2012) - Sernova Corp. ("Sernova" or the "Company") (TSX VENTURE:SVA) is pleased to announce a non- brokered private placement (the "Offering") of up to 19,444,444 units of the Company ("Units") at a price of $0.18 per Unit for gross proceeds of up to $3.5 million, of which $2.5 million has been secured.

Each Unit will consist of one common share of the Company (a "Share") and one common share purchase warrant (a "Warrant"). Each Warrant will entitle the holder thereof to purchase one Share (a "Warrant Share") for a period of three years, at a price of $0.20 per Warrant Share in the first year and at a price of $0.35 per Warrant Share in the second and third years.

"Securing these funds represents a key milestone for Sernova and a testament to continued strong investor support," stated Dr. Philip Toleikis, President and CEO. "These funds will enable Sernova to initiate the planned clinical study to investigate the safety and efficacy of the Cell Pouch(TM) in diabetic patients receiving islet cell transplantation. This study, which will be initiated in the second quarter of 2012, will represent a significant step towards a new and potentially effective treatment that would improve the quality of life in patients with diabetes."

The Units will be made available by way of private placement exemptions in Canada under National Instrument 45-106 - Prospectus and Registration Exemptions.

The Offering is subject to acceptance by the TSX Venture Exchange. All securities issued in connection with the Offering will be subject to a statutory hold period of four months plus one day from the date of completion of the Offering, in accordance with applicable securities legislation.

The proceeds from the Offering will be used by Sernova for research and development of its proprietary Cell Pouch System(TM) and in particular to fund the upcoming first in man clinical trial for patients with diabetes receiving an islet transplant. The funds will also be used for general and administrative expenses. This clinical trial will be conducted at the University of Alberta with Dr. James Shapiro as principal investigator. Dr. Shapiro is world renowned for advancing cutting edge technologies in the islet transplantation field and was instrumental in developing the Edmonton Protocol. The study will assess both safety and efficacy of the Cell Pouch System(TM) in up to 20 patients with unstable diabetes. In this study, patients will be implanted with Sernova's Cell Pouch(TM) and then transplanted with islets. Safety and efficacy will be monitored throughout the study.

About Sernova

Sernova Corp. is a Canadian-based, health- sciences company focused on commercializing medical technologies. Sernova is currently developing a platform technology for a number of serious disease indications, starting with a novel treatment for insulin- dependent diabetes, using the novel Cell Pouch System(TM) and its patented Sertolin(TM) cell technology.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words "expects", "plans", "anticipates", "believes", "intends", "estimates", "projects", "potential" and similar expressions, or that events or conditions "will", "would", "may", "could" or "should" occur. Although Sernova believes the expectations expressed in such forward- looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of Sernova's management on the date such statements were made. Sernova expressly disclaims any intention or obligation to update or revise any forward- looking statements whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

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Press Release Communiqué de presse - January 19, 2012 19 January, 2012

Sernova Receives Patent Allowance in Japan


January 19, 2012, 6:00 a.m. EST

LONDON, ONTARIO--(Marketwire -- Jan. 19, 2012) - Sernova Corp. (TSX-V: SVA), today announced that the Japan Patent Office has issued a Notice of Allowance to Sernova for a patent entitled "Compositions Containing Sertoli Cells and Myoid Cells and Use Thereof in Cellular Transplants." Allowance in additional international jurisdictions including Canada, Europe, and the United States is pending while allowance in Australia has been granted.

"This patent allowance further strengthens our patent portfolio of over 22 issued and pending patents covering our enabling platforms of therapeutic cells, local immunoprotection and medical devices, including the Cell Pouch System(TM)," said Dr. Philip Toleikis, Sernova's President and CEO. "The claims in this patent position Sernova to expand its platform to a wide range of therapeutic cell types, which are important in treating chronic diseases, and enable us to further establish partnering and development opportunities as we continue to advance our Cell Pouch System(TM). Our upcoming evaluation of the Cell Pouch(TM) in patients with diabetes is part of this important process."

Sernova has presented compelling evidence at leading scientific conferences demonstrating that the Cell Pouch System(TM) can be used as a safe and effective platform for delivery of insulin from both autograft (self) and allograft (donor) islets to restore glucose control in stringent preclinical models of diabetes using the human scaled product. Sernova is currently preparing for safety and efficacy evaluation of the Cell Pouch System (TM) in humans in the first study of its kind in the world.

In the future, Sernova plans to explore the additional utility of the Cell Pouch System(TM) as an enabling platform for a range of therapeutic cell types with the potential to treat multiple chronic debilitating diseases where there are broad unmet medical needs.

About Sernova

Sernova Corp. is a Canadian-based health sciences company focused on product development and commercialization of innovative proprietary platform medical technologies in the cell therapy arena such as the Cell Pouch System(TM) to provide a safe and efficacious environment for therapeutic cells and Sertolin(TM), a technology which, when combined with cell therapy, may protect therapeutic cells without the need for patients to take anti-rejection drugs. Sernova's first cell therapy application is for insulin-dependent diabetes to reduce or eliminate the need for insulin injections.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release contains forward-looking information, which involves known and unknown risks, uncertainties and other factors that may cause actual events to differ materially from current expectation. Important factors - including availability of funds, the results of financing efforts, the results of research and product development activities -- that could cause actual results to differ materially from Sernova's expectations are disclosed in Sernova's documents filed from time to time on SEDAR (see www.sedar.com). Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. The company disclaims any intention or obligation, except to the extent required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

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Press Release Communiqué de presse - January 09, 2012 9 January, 2012

Sernova to Present Company and Clinical Update at Biotech Showcase™ San Francisco


January 9, 2012, 6:00 a.m. EST

LONDON, ONTARIO--(Marketwire -- Jan. 9, 2012) - Sernova Corp. (TSX-V: SVA), today announced that Dr. Philip Toleikis, Ph.D., President and CEO of Sernova, will present an update on the company's technology and its plans to initiate patient enrollment in a Phase I/II clinical trial for its Cell Pouch(TM) System at 11 a.m. PST, Monday, Jan. 9, at the Biotech Showcase(TM). The conference will be held at Parc 55 Wyndham Union Square Hotel in San Francisco.

Based on positive preclinical results, Sernova is preparing for the initiation of human clinical studies where patients with diabetes will be implanted with the Cell Pouch(TM) followed by transplantation of donor islets. The Cell Pouch(TM) has been designated as a medical device for regulatory purposes and Dr. James Shapiro (University of Alberta, Edmonton) developer of the Edmonton Protocol will be the principal clinical investigator for the diabetes study.

About the Biotech Showcase(TM) (Innovation -- Opportunity -- Collaboration):

Now in its fourth year, Biotech Showcase(TM) will feature corporate presentations by 200+ innovative life science companies to an audience of public and private investors, business development executives and professional advisors who are interested in investment opportunities and collaboration. Biotech Showcase was co- founded by Demy-Colton Life Science Advisors and EBD Group, two organizations that have a long and successful history building programs that meet the needs of the life sciences industry. Visit our website for more information: www.ebdgroup.com/bts.

About Sernova

Sernova Corp. is a Canadian-based health sciences company focused on product development and commercialization of innovative proprietary platform medical technologies in the cell therapy arena such as the Cell Pouch System(TM) to provide a safe and efficacious environment for therapeutic cells and Sertolin(TM), a technology which, when combined with cell therapy, may protect therapeutic cells without the need for patients to take anti-rejection drugs. Sernova's first cell therapy application is for insulin-dependent diabetes to reduce or eliminate the need for insulin injections.

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: (604) 961-2939 info@sernova.com www.sernova.com

Tony Russo, Ph.D. Russo Partners, LLC Tel: (212) 845-4251 tony.russo@russopartnersllc.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release contains forward-looking information, which involves known and unknown risks, uncertainties and other factors that may cause actual events to differ materially from current expectation. Important factors - including availability of funds, the results of financing efforts, the results of research and product development activities -- that could cause actual results to differ materially from Sernova's expectations are disclosed in Sernova's documents filed from time to time on SEDAR (see www.sedar.com). Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. The company disclaims any intention or obligation, except to the extent required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.